New study shows ribose plus caffeine may be superior at fighting fatigue.

December 17th, 2013
coffee and snacks

Most people don’t reach for energy drinks unless they are drowsy and have exhausted their energy reserves. Others depend on a candy bar to get them past their mid-afternoon energy slumps. While we know that caffeine, ribose and glucose provide energy benefits, Bioenergy Life Science researchers recently became the first team to test these ingredients using a fatigue model. The goal was to assist product formulators by determining the best possible ingredient synergies. The exciting results may lead to changes in the ingredient ratios used in energy products.

“In previous studies, the effects of these ingredients were evaluated on people under normal conditions,” explained Alex Xue, Ph.D., executive VP & chief technology officer, Bioenergy Life Science. “What made this fatigue model experiment different was that it showed us what happens when you give caffeine and/or ribose to subjects who are already fatigued and have used up their energy reserves. That’s relevant because it is a more real-world example of how these products are used.”

How the study was conducted

For this study, researchers used a standard mice fatigue model. Previous research has shown that ribose and caffeine have similar impacts on mice and humans.

For three days prior to the start of the experiment, mice swam to the point of exhaustion so that their energy reserves were low. During the actual experiment, the mice swam in the morning and afternoon for three days. On the third day, their swimming time dropped more than 20 percent compared to their baseline average over the first two days.

On day four, the mice were fed their normal diet plus one of four treatments. Then their endurance was once again tested by how long they were able to swim. The results:

Glucose only: Swimming time returned to about the same as their normal baseline average (100 percent).

Caffeine only: Swimming time dropped, and became worse than baseline.

Ribose only: Swimming time improved to 135 percent.

50/50 ribose and caffeine combination: Swimming time improved by 150 percent.

“In the second stage, we used different ribose/caffeine concentrations. We determined that the optimal combination – when translated into human equivalents – is 10mg/kg caffeine plus 4 grams of ribose. With this combination, we could boost swimming time to 180 percent! Though this is the optimal combination, it should be noted that lower doses of ribose also improve the swimming time,” says Xue. He added, “When the caffeine concentration was higher, the effect was negative. This could be because we were providing too much stimulant (caffeine) without base energy (ribose) to fill the order. This makes sense because we know that ribose helps the heart to relax, and a relaxed heart can function more efficiently. Caffeine, on the other hand, can make the heart more exhausted because it causes the heart rate to become quick and shallow.” Bioenergy Ribose was used in this experiment.

Xue says that human clinical studies will be conducted to further verify these findings.

 

Bioenergy Ribose: Your answer for a fatigued nation

December 3rd, 2013
Mature man sitting in the garden yawning

Last week, we mentioned that we received enthusiastic feedback from SupplySide West attendees about results of a new ribose/caffeine study. We’re confident that when this information becomes better known, the demand for Bioenergy Ribose will skyrocket among product formulators as well as consumers looking for more effective energy product alternatives.

But just how easy is it to formulate with Bioenergy Ribose? It’s simple!

• It tastes good!

• It acts like sugar in a food system, and is a monosaccharide and a reducing sugar in food.

• It is easily soluble and dissolves in most food systems.

• It is stable in most pHs common in food, ranging through acid, neutral and alkaline.

• It participates in the browning or maillard reaction in food systems, especially upon heating.

• It is compatible with other sugars, carbohydrates and sweeteners in formulations.

• It is compatible in protein-based systems.

• It is compatible with chocolates.

Bioenergy Ribose presents food and beverage manufacturers with a broad spectrum of opportunities. Bioenergy Ribose is an all-natural substance, with a slightly sweet taste, allowing for easy incorporation into the formulations of a variety of nutritional food and beverage products.

Bioenergy Ribose has undergone extensive clinical testing, and has been proven effective as a functional ingredient by providing:

• Faster energy recovery

• Increasing energy reserves

• Building ATP in skeletal and cardiac tissue

• Maintaining healthy energy levels in heart and muscle

• Regenerating energy

Bioenergy Ribose has been clinically evaluated in numerous areas, including sports nutrition and cardiovascular health. For a complete list of published clinical studies on Bioenergy Ribose, visit

www.bioenergyribose.com/the-science/clinical-studies/additional-studies.

 

SupplySide West 2013: Industry reacts positively to caffeine study

November 20th, 2013
Bioenergy SSW 2013 2

SupplySide West 2013 may be history, but it sparked conversations about the future uses of ribose that will continue for a long time to come. Among the hottest topics of conversations was the results of a new study showing that combining d-ribose with caffeine significantly reduced caffeine usage level and provided sustained energy for much better performance. Bioenergy Ribose was used in this study.

Bioenergy Life Science President Tom VonderBrink was thrilled with the industry’s reaction. “We had great reception and positive comments on the caffeine study. It was exciting to have something so timely and significant to discuss with attendees.” Previous studies have shown that combining ribose with reasonable dosages of caffeine may be a logical synergy.

Elite Team Ribose athletes: “before and after” ribose

Susan After

Olympian Susan Francia had fun getting to know attendees who stopped by our booth. She’d hold up her smaller gold medal from the Beijing Olympics and say with a grin, “Before ribose” … then hold up the significantly larger gold medal she earned in London and say, “After ribose!”

Then she’d get down to business, explaining how Bioenergy Ribose helps her with muscle and energy recovery, getting her through a back injury and ready for the Olympics. Ribose gave her the energy she needed to get through one workout, and then be recovered and full of energy for the next workout. “I had a great time meeting people and talking about Bioenergy Ribose,” she says of SupplySide West. “I thought the convention was a hit and we made a lot of good contacts.”

Added Olympian Billy Demong, “I was really impressed with SupplySide West! There was a lot of energy, and a lot of good nutritional products were represented. It was exciting being in the Bioenergy Ribose booth. So many people came by to talk about ways to include Bioenergy Ribose into their products because they know about its many great benefits.”

 

The Better Show viewers learn about Bioenergy Ribose and sustained energy

June 12th, 2013
Better TV

People often need an energy boost to keep up with their demanding lives, but is caffeine alone enough? Caffeine is a stimulant; it can’t create more energy once you’ve exhausted your stores. Co-hosts Audra Lowe and JD Roberto invited holistic pharmacist and author Sherry Torkos to their show to discuss the alternatives. She recommends Bioenergy Ribose. Ribose occurs naturally in each cell and accelerates the reformation of ATP, the source of cellular energy. Taking ribose regularly may improve cell recovery, lower muscle fatigue and help maintain higher energy levels.

Energy drinks: The advantages of combining Bioenergy Ribose and caffeine

April 22nd, 2013
Energy drink cans

Are you one of those people who just can’t function until they’ve had their morning cup of coffee? Join the crowd! About 90 percent of Americans consume caffeine daily. In addition to coffee, tea or cola, energy drinks made with caffeine are growing in popularity. So it may surprise you to learn that caffeine does not produce energy. It acts as a stimulant. Here’s why combining ribose and reasonable doses of caffeine may be a logical synergy.

Caffeine stimulates the brain’s cortex, stimulating the body’s ‘fight or flight’ stress response and increasing adrenaline levels. This causes us to temporarily feel more alert, less drowsy and in a better mood. (Who hasn’t known someone who spurns conversation until they’ve finished their first cup of coffee?)

But when caffeine’s effects begin to diminish and those levels of adrenaline decrease (the half-life for caffeine in healthy adults is about five hours), we may start to feel fatigued and possibly even a little depressed. Some of us may try to counteract these feelings by reaching for more caffeine. Consuming too much caffeine may lead to sleep disorders, increased heart rate, as well as feelings of nervousness, headaches, occasional lightheadedness, and the “jitters.” In some cases, it can even exacerbate stress.

This is why Bioenergy Ribose may be an ideal complement to caffeine, and offer a real advantage when included in energy drinks. Ribose enhances ATP recovery following stress without significant adverse effects. It also enhances muscle performance and increases tolerance to stress. Studies have also found that ribose may enhance sleep quality and duration, and may improve vitality, social outlook and mental awareness.

It makes sense that beverage formulas featuring both ingredients should produce the combined benefits of ribose and caffeine, while ribose also helps to mitigate some of caffeine’s less desirable effects. The result may be energy products that give us that boost we crave plus enhanced sports performance, and that are better at reducing the energy drain and other unwanted effects we might feel as the result of a caffeine “crash.”